Generic Name: duloxetine (du LOX e teen)
Brand Names: Cymbalta, Irenka

What is Duloxetine?

Duloxetine is an SSNRI which means selective serotonin and norepinephrine reuptake inhibitor. It is an anti-depressant used to treat depression. SSNRI’s work by recycling serotonin and norepinephrine and by blocking it re-entering the cell it came from, the problem with this is if you have little to no serotonin they won’t work like they should.
Duloxetine is used to treat major depressive disorders in adults, but can be used to treat anxiety in children over the age of 7 and adults too, is also used to treat pain conditions like fibromyalgia and diabetic neuropathy.


You should tell your doctor if you have:

  • Liver disease
  • Kidney disease;
  • Seizures
  • Epilepsy
  • Bleeding disorder
  • Blood clotting disorder
  • High blood pressure
  • Narrow-angle glaucoma
  • Bipolar disorder
  • Manic depression
  • Drug addiction
  • Suicidal thoughts

Do not take

You should not take this medication if you have used an MAO inhibitor within the last 5-14 days.
It could be very dangerous as certain medications can interact with each other

MAO inhibitors include:

  • Isocarboxazid
  • Linezolid
  • Methylene
  • Blue injection
  • Phenelzine
  • Rasagiline
  • Selegiline
  • Tranylcypromine

Side effects of taking duloxetine

  • Suicidal
  • Light-headed
  • Eye problems
  • Bruising
  • Unusual bleeding
  • Painful or difficult urination
  • Headache
  • Seizures
  • Stomach pain
  • Skin pain, blistering and peeling
  • Swelling in your face or tongue
  • Itching
  • Dark urine 
  • Jaundice
  • Sore throat
  • Loss of coordination
  • Manic behaviour
  • Confusion
  • Burning in your eyes
  • Liver problems
  • Slurred speech
  • Severe weakness
  • Vomiting
  • Feeling unsteady
  • Fever

For a full list of side effects see here